Animal Resources

Supporting research studies by providing the highest standards of animal care leading to improved reproducibility.

  • Animal use protocol development and ethics approval

  • Veterinary oversight and compliance support

  • Animal handling and technical training

  • Custom mouse breeding, weaning, and colony expansion

  • Technical services including sample collection, drug administration and surgery

Model Production

Providing genetically engineered mice for investigating gene function and testing therapeutic intervention.
  • Allele design and vector construction for targeting and transgenics

  • Production, and quality control of mouse mutant lines using Cas9, ES cells, or transgenics

  • Gene targeting and quality control in mouse embryonic stem (ES) cells

  • Generation of chimeras including tetraploid complementation assay

  • Derivation of new mouse ES cells and embryonic fibroblasts

  • Colony management and genotyping for research cohort production

Clinical Phenotyping

Identifying clinical phenotypes of mouse models of human disease using internationally standardized in vivo tests.
  • Custom in-life phenotyping across major physiological and neurological systems

  • Morphology assessment & sensory testing (thermal, mechanical, olfactory, auditory, visual)

  • Organ function, including heart, kidney, blood, musculoskeletal

  • Neurobehaviour analysis for learning and memory, trait anxiety, depression, social behaviour

  • Preclinical testing of treatments with clinical phenotyping

Imaging

Discovering complex morphological and developmental phenotypes that lead to new hypotheses about disease mechanisms.

  • High-throughput 3D imaging to study mouse embryo and adult anatomy

  • Magnetic resonance imaging (MRI), X-ray micro-computed tomography (┬ÁCT), High-frequency ultrasonography, Optical projection tomography, and Serial two-photon fluorescence microscopy

  • Image analysis, image visualization, and 3D mouse atlases

Pathology

Identifying histological changes associated with disease and therapeutic interventions.

  • Gross pathology including whole body necropsy or organ-specific dissection

  • Clinical chemistry with blood collection and analysis of up to 18 analytes

  • Histology with fixed or frozen tissue processing and sectioning, routine or special staining

  • Immunohistochemistry with automated high-throughput single and multiplex fluorescence

  • Digital pathology with whole slide imaging and quantitative image analysis

  • Histopathology for research interpretation and evaluation

Archiving & Distribution

Securing and distributing valuable mouse resources to promote research reproducibility, collaboration and impact.
  • Sperm and embryo cryopreservation for long-term storage and biosecurity

  • Sperm and embryo cryorecovery to re-establish lines from cryopreserved stock

  • Rederivation or rescue of mouse strains into specific pathogen-free status

  • Distribution of cryopreserved or recovered lines

Service Partners

TCP collaborates with multiple research service providers to ensure our clients have access to cutting-edge technologies across domains for their research projects

  • Infection studies with bacteria, viruses, parasites, and fungi in CL2 and CL3 as well as inflammatory models are supported by our collaborators at the McGill Infection and Inflammation Platform

  • Proteomics and metabolomics studies, including several quantitative mouse tissue proteomics assays developed in collaboration with TCP, can be executed at the Proteomics Centre at the University of Victoria

  • Sanger and next generation sequencing for quality control of animal models are conducted at The Centre for Applied Genomics

Work with us

We are Canada’s platform for discovery and biomedical research using mouse models.

Funding Partners