Publications

Please acknowledge the contributions of TCP staff and resources in your presentations and published work.

In the acknowledgements section, e.g., “The authors wish to acknowledge the contribution of the [service core e.g. Model Production, Pathology] at The Centre for Phenogenomics for [activity – e.g colony management, generation of mutant mice, phenotyping, histology]”.

Or in the methods section, e.g., “[Activity/Resource] was performed/provided by [service core] at The Centre for Phenogenomics”.

For all animal studies performed at TCP, “All procedures on animals at The Centre for Phenogenomics (TCP) were reviewed and approved by TCP’s Animal Care Committee. TCP is certified by the Canadian Council on Animal Care and registered under the Animals for Research Act of Ontario.”

Raghuram et al. 2024. Elevated expression of wildtype RhoC promotes ErbB2- and Pik3ca-induced mammary tumor formation. Breast Cancer Res. 2024 May 28;26(1):86.

RHO protein overexpression and/or activation is linked to poor prognosis in breast cancer. To study this, Dr. Nandini Raghuram and colleagues in Dr. Sean Egan’s lab at The Hospital for Sick Children developed a conditional RhoC overexpressing mouse and crossed it with two different models of breast cancer, one overexpressing Erbb2 and one with an activating mutation in Pik3ca. In both cases, RhoC overexpression enhanced mammary tumor formation and invasive behaviour of the resulting tumors. These data highlight the therapeutic potential of targeting RHO protein expression in the clinic.

Dr. Egan commented that “…the [Model Production] Core helped with experimental design for targeting the ROSA26 safe-harbour locus and the generation of transgenic animals.”