The Centre for Phenogenomics
Catalyzing discovery. Creating knowledge. Improving health.
Developing and phenotyping new mouse models of development and disease
The Centre for Phenogenomics (TCP) is a national facility that supports cutting-edge research and discovery using mouse models. Our team of experts and the state-of-the-art infrastructure of TCP are available to help scientists advance their research programs. Leverage our expertise for all aspects of your mouse research so you can focus on data interpretation and research outcomes.
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“[TCP] helped generate the whole environment you need…What [TCP] really brings to the table is the willingness to understand on a deep level and then make it happen.”
Daniel Schramek, Senior Investigator, LTRI,
Associate Professor (Molecular Genetics, University of Toronto)
“[TCP] helped generate the whole environment you need…What [TCP] really brings to the table is the willingness to understand on a deep level and then make it happen.”
Daniel Schramek, Senior Investigator, LTRI, Associate Professor (Molecular Genetics, University of Toronto)
Research Spotlight
Raghuram et al. 2024. Elevated expression of wildtype RhoC promotes ErbB2- and Pik3ca-induced mammary tumor formation. Breast Cancer Res. 2024 May 28;26(1):86.
RHO protein overexpression and/or activation is linked to poor prognosis in breast cancer. To study this, Dr. Nandini Raghuram and colleagues in Dr. Sean Egan’s lab at The Hospital for Sick Children developed a conditional RhoC overexpressing mouse and crossed it with two different models of breast cancer, one overexpressing Erbb2 and one with an activating mutation in Pik3ca. In both cases, RhoC overexpression enhanced mammary tumor formation and invasive behaviour of the resulting tumors. These data highlight the therapeutic potential of targeting RHO protein expression in the clinic.
Dr. Egan commented that “…the [Model Production] Core helped with experimental design for targeting the ROSA26 safe-harbour locus and the generation of transgenic animals.”