The Centre for Phenogenomics

Catalyzing discovery. Creating knowledge. Improving health.

The Centre for Phenogenomics

Catalyzing discovery. Creating knowledge. Improving health.

The Centre for Phenogenomics

Catalyzing discovery. Creating knowledge. Improving health.

Developing and phenotyping new mouse models of development and disease

The Centre for Phenogenomics (TCP) is a national facility that supports cutting-edge research and discovery using mouse models. Our team of experts and the state-of-the-art infrastructure of TCP are available to help scientists advance their research programs. Leverage our expertise for all aspects of your mouse research so you can focus on data interpretation and research outcomes.

Production staff extracting RNA for molecular quality control of a new mouse line.
Production staff extracting RNA for molecular quality control of a new mouse line.

TCP powers research

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Mouse lines created
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Our services

“[TCP] helped generate the whole environment you need…What [TCP] really brings to the table is the willingness to understand on a deep level and then make it happen.”

Daniel Schramek, Senior Investigator, LTRI,
Associate Professor (Molecular Genetics, University of Toronto)

“[TCP] helped generate the whole environment you need…What [TCP] really brings to the table is the willingness to understand on a deep level and then make it happen.”

Daniel Schramek, Senior Investigator, LTRI, Associate Professor (Molecular Genetics, University of Toronto)

Immunofluorescence image of embryonic day 6.25 mouse embryos expressing Oct4-mCherry, H2B-GFP and DAPI
Immunofluorescence image of embryonic day 6.25 mouse embryos expressing Oct4-mCherry, H2B-GFP and DAPI

Research Spotlight

Posfai et al. 2020. Evaluating totipotency using criteria of increasing stringency. Nature Cell Biology 23:49-60.

Research from the lab of Dr. Janet Rossant at The Hospital for Sick Children re-assessed the totipotency of two recently published embryonic stem cell lines by comparing transcriptomes, gene regulatory networks and developmental potential with pre- and post-implantation mouse embryos. This work sets a new “gold standard” framework with which to assess totipotency in future analyses.

Congratulations to the authors and thank you for your gracious acknowledgement of TCP.

Work with us

We are a national facility, producing and phenotyping mouse models for discovery and biomedical research.