Organization and Objectives
The Centre for Phenogenomics (TCP, formerly "Toronto Centre for Phenogenomics") is owned and operated by Mount Sinai Hospital and The Hospital for Sick Children as a centralized, state-of-the-art national research facility. Open since 2007, TCP provides animal holding, model production, clinical phenotyping, infection and inflammation, imaging, pathology, and cryopreservation and recovery services to users locally, across Canada and around the world.
What We Do
The strength of TCP is our collective expertise and unique ability to design, generate, hold, analyze, archive, and distribute a critical mass of mouse models under one roof. We provide:
- Custom services for the generation of genetically engineered mouse models
- Mouse holding and technical services for preclinical in vivo research projects
- Comprehensive or disease-specific phenotyping, host response analysis to in vivo immunological challenges and pathology services for research, and drug discovery and evaluation
- Biorepository services to archive, acquire, and distribute mouse models
Research and Ethics
TCP is committed to the highest standards of animal ethics and care in science. All studies meet the requirements of the provincial legislation and regulations of the Animals for Research Act as well as the national guidelines and policies of the Canadian Council on Animal Care and are approved by TCP Animal Care Committee.
Dr. Lise Phaneuf, Director, Research & Facility Operations
Dr. Colin McKerlie, Director, Research Partnerships
Dr. Mark Henkelman, Director, Mouse Imaging Centre (MICe)
Dr. Silvia Vidal, Director, Infection & Inflammation Core
Dr. Danielle Malo, Co-director, Infection & Inflammation Core